- Low platelet count.
Platelet count below 100,000.
Platelet count below
50,000 increases the risk of hemorrhage.
Plattelet count of 10,000 to 15,000 may cause
A platelet count below 10,000 can be
Early signs of thrombocytopenia.
May have bleeding from mucosa.
Most common severe bleeding may be from the brain or GI track.
Occasionally may have pericardial bleeding or bleeding from the lungs.
Bleeding of the gums.
Blood in stool.
Occasionally blood will react with EDTA an anticoagulant used in blood
This causes platelets to clump to gether and adhere
to white blood cells causing a false low platelet count.
Additional Labs should be done.
Activated partial thromboplastin time.
platelet antibody studies.
bone marrow biopsy.
Types of thrombocytopenia
The key types of thrombocytopenia are druginduced, idiopathic, and
Activated antibodies remove the
platelets from circulation.
Reduces platelets after starting a new drug.
Platelets may clump together causing arterial or
Most common cause is heparin.
Usually discontinuing the drug takes care of the problem.
Paletelets may have a shorter life span.
Spleen contains 30% to 40% of platelets
Accumulation of platelets in the
Idiopathic thrombocytopenia purpuva
Formation of antiplatelet antibodies.
more susceptible to phagocytosis and destruction in the spleen.
Widespread thrombi in the arterioles and capillaries
Caused by endothelial injury.
Release of procoagulant substances from the
Decreased or defective platelet production.
Malignant cells in the bone marrow.
Nonimmune destruction - the mechanical destruction of platelets.
Intraaortic balloon pump.
Prosthetic heart valves. causes
Caused by multiple transfusions of packed red blood cells which
10 units in twenty four hours.
Bleeding itself results in a loss of platelets.
Treatment of thrombocytopenia
Since there are several causes of thrombocytopenia treatment
Review patient medication.
Discontinue those drugs which may cause
Increase platelet production.
Lithium carbonate or foliate will help the bone
Platelet transfusion may be given.
Splenectomy should be considered to remove the
source of platelet
Plasmaphoresis could be used to separate from whole
components that may cause thrombocytopenia.
Fresh frozen plasma (FFP) may be used to assist in
the control of