Drugs commonly administered by iv infusion in the ICU

AMRINONE (150 mg ampl) 

Loading Dose: 0.75 mg/kg (in 2-3 min)Bolus doses can be administered undiluted. 
repeate once in 30 minutes.
Maintenance Dose: 5-10 ug/kg.min
Dilution: 200 mg/250 ml (0.9% NaCl)
Final Concentration: 0.8 mg/ml

Comments:Infusion solution must not contain dextrose; can induce thrombocytopenia; 
potentiates warfarin anticoagulation

Amrinone Inocor

Dose:
Usual Dose: 2-20 mcg/kg/min.
Total daily dose < 10 mg/kg/day.
Wean when discontinuing medication.

Mix: 500 mg in 250 NORMAL SALINE ONLY
100mg in 100ml of NaCl.
Dose: 5-10 mcg/kg/min

Action: Rapid acting inotropic. vasodilator similar to dobutamine

Use: Management of patient with severe CHF that has not responded to diuretics, digitalis, and afterload reduction.

CHF refractory to diuretics, vasodilators and conventional intropics.

Load with 1mcg/kg then 2-15 mcg/kg/min
* Monitor for tachyarrhythmias * Do not mix with dextrose solutions.

 

BIBLIOGRAPHY

  1. Firth B, Ratner AV, Grassman ED, et al: Assessment of the inotropic and vasodilator effects of amrinone versus isoproterenol. Am J Cardiol 1984; 54:1331
  2. Franciosa JA: Intravenous amrinone: An advance or a wrong step? Ann Intern Med 1984; 54:1331
  3. Colucci WS, Wright RF, Braunwald E: new positive inotropic agents in the treatement of congestive heart failure (Parts 1 and 2). N Engl J Med 1986; 314:290, 394
  4. Likoff MJ, Weber KT, Andrews V, et al: Amrinone in the treatement of chronic heart failure. J Am Coll Cardio 1984, 3:1282
  5. Zaritsky AL, Chernow N: Catecholamines and other inotropes. In: The Pharmacological Appoach to the Critically Ill Patient. Second Edition. Chernow B(Ed). Baltimore, Williams & Wilkins, 1988, pp596-598

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