Thrombocytopenia
- Low platelet count.
nursebob
Thrombocytopenia
Platelet count below 100,000.
Platelet count below
50,000 increases the risk of hemorrhage.
Plattelet count of 10,000 to 15,000 may cause
spontanous bleeding.
A platelet count below 10,000 can be
fatal.
Early signs of thrombocytopenia.
Petechiae.
Purpura over
several days
May have bleeding from mucosa.
Most common severe bleeding may be from the brain or GI track.
Occasionally may have pericardial bleeding or bleeding from the lungs.
Hemmorrhagic disorders.
Bloody urine
Bleeding of the gums.
Blood in stool.
Bloody sputom.
Multiple petechiae
Scleral hemorrhage
Ecchymosis.
False Thrombocytopenia.
Occasionally blood will react with EDTA an anticoagulant used in blood
collection tubes.
This causes platelets to clump to gether and adhere
to white blood cells causing a false low platelet count.
Additional Labs should be done.
CBC.
Bleeding time
Prothrombin time.
Activated partial thromboplastin time.
platelet antibody studies.
platelet survival
studies
bone marrow biopsy.
Types of thrombocytopenia
The key types of thrombocytopenia are druginduced, idiopathic, and
thrombotic.
Drug-induced thrombocytopenia.
Immune reaction.
Activated antibodies remove the
platelets from circulation.
Reduces platelets after starting a new drug.
Platelets may clump together causing arterial or
venous thrombosis.
Drugs
Most common cause is heparin.
Sulfonamides
Quinine
Chemotherapy.
Usually discontinuing the drug takes care of the problem.
Radiation.
Idiopathic
Paletelets may have a shorter life span.
Splenomegaly
Spleen contains 30% to 40% of platelets
Accumulation of platelets in the
spleen.
Idiopathic thrombocytopenia purpuva
Autoimmune disorder.
Formation of antiplatelet antibodies.
Platelets
more susceptible to phagocytosis and destruction in the spleen.
Thrombocytopenic purpuva
Widespread thrombi in the arterioles and capillaries
in the
microcirculation.
Caused by endothelial injury.
Release of procoagulant substances from the
endothelial cells.
Thrombotic
Decreased or defective platelet production.
Aplastic anemia.
Malignant cells in the bone marrow.
HIV
Nonimmune destruction - the mechanical destruction of platelets.
Intraaortic balloon pump.
Prosthetic heart valves. causes
Pseudothrombocytopenia
Caused by multiple transfusions of packed red blood cells which
do not
contain platelets.
10 units in twenty four hours.
Bleeding itself results in a loss of platelets.
Hypothermia.
Treatment of thrombocytopenia
Since there are several causes of thrombocytopenia treatment
will vary.
Review patient medication.
Discontinue those drugs which may cause
thrombocytopenia.
Increase platelet production.
Corticosteroids.
IV
imunoglobulin (IGG).
Lithium carbonate or foliate will help the bone
marrow stimulate
platelet production.
Platelet transfusion may be given.
Splenectomy should be considered to remove the
source of platelet
destruction.
Plasmaphoresis could be used to separate from whole
blood those
components that may cause thrombocytopenia.
Fresh frozen plasma (FFP) may be used to assist in
the control of
bleeding.
********************************************